DESIGN DEVELOPMENT AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF RANITIDINE HYDROCHLORIDE

The aim of this study was to develop an innovative fast dissolving oral film of Ranitidine HCl based on polymers such as Hydroxy Propyl Methyl Cellulose-E6, Hypromellose-E3 LV, and Polyvinyl alcohol. Trials on various concentrations of polymers were conducted in order to optimize polymer concentration and develop the films with best suitability and acceptability. The various concentrations of super disintegrating agents like Crospovidone, Croscarmellose sodium and Sodium Starch Glycolate were evaluated. The fast dissolving oral films were characterized for weight, thickness, folding endurance, disintegration and dissolution using in vitro experimentations. The effect of super disintegrating agents on drug release profile and film forming properties was investigated. The prepared films exhibited satisfactory physicochemical characteristics. Finally, it is concluded that Ranitidine can be formulated with Hydroxy Propyl Methyl Cellulose-E6, Hypromellose-E3 LV, and Polyvinyl Alcohol polymers to achieve oral film formulation by using solvent casting method.