DESIGN AND EVALUATION OF DOMPERIDONE FAST DISINTEGRATING TABLETS BY WET GRANULATION TECHNIQUES USING PLANTAGO OVATA MUCILAGE

In the present study, fast disintegrating tablets of domperidone were prepared to enhance patient compliance by wet granulation method. In the study, fast disintegrating tablets of the drug using, Plantago ovata mucilage and Crospovidone were used as superdisintegrants (2.5 to 10 % w/w) along with starch paste as a binder. The disintegrant was incorporated during the wet granulation process as an extra granular incorporation. The prepared tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 12 s), the two formulations were tested for in vitro drug release, short term stability (at 400/75% RH for 3 months) and drug excipient interaction (IR spectroscopy). Among the two promising formulations, the formulations prepared by using 10% w/w of Plantago ovata mucilage and 32% w/w of starch paste emerged as the overall best formulation (t50% 2.90 min) compared to conventional commercial tablets formulations (t50% 7.85 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p