SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF SOME NEW ORGANIC TELLURIIUM COMPOUNDS CONTAINING THIADIAZOLES

A new (2-(2-(5-Mercapto-1,3,4-thiadiazol-2-yl)hydrazinyl)-3,5-dinitrophenyl) tellurium tribromide compound(2) was prepared by the reaction of (2-(2-(5-Mercapto-1,3,4-thiadiazol-2-yl)hydrazinyl)-3,5-dinitrophenyl)mercury(II)chloride (1)with tellurium tetrabromide in 1:1 ratio in dry dioxane solvent. Later compound(2)reacted with solution of sodium pyrrolidenedithiocarbamate, sodium piperidinedithiocarbamate or sodium morpholinedithiocarbamate in a 1:3 ratio to produce new Tri (pyrrolidinedithiocarbamato)(2-(2-(5-mercapto-1,3,4-thiadiazol-2-yl) hydrazinyl)-3,5-dinitrophenyl)tellurium(3), Tri(piperidinedithiocarbamato)(2-(2-(5-mercapto-1,3,4-thiadiazol-2-yl)hydrazinyl)-3,5-dinitrophenyl)tellurium (4) or Tri (morpholinedithiocarbamato)(2-(2-(5-mercapto-1,3,4-thiadiazol-2-yl)- hydrazinyl)-3,5-dinitrophenyl) tellurium (5), respectively. The structures of all newly synthesized compounds were assigned on the infrared, uv-visible , 1H&13C NMR and mass spectra. The antibacterial activity of the new compounds were tested with agar diffusion method against the bacteria strains Staphylococcus aureus and Escherichia coli.