A Rare Case of Co-Morbidity: Glioblastoma on HIV Infected Patient with more than Two-Year Survival

Introduction: During HIV infection, immunity deficiency promotes the development of some tumors such as glioblastomas witch are central nervous system malignant tumors with a high astrocytary differentiation. Their prognosis is poor with an average survival ranged between 12 and 15 months. Objective: To report a case of glioblastoma in an HIV infected patient with more than 24 months of survival. Methodology: We achieved a document review of patient that is followed up in our department for HIV infection and who developed a glioblastoma. Case: A 41 year-old HIV1 infected black man, treated presented some encephalic signs (headaches, mental confusion, nauseas and vomiting) without neurological localization. He was treated by the highly active antiretroviral therapy (HAART) two years ago, and had an immunovirological success six months after the beginning of the HAART. CD4 rate was 315 cells/mm3 with undetectable viral load. Cerebral CT scan founded a right temporo-polar expensive process and right cerebral parenchyma edema. The anatomo-pathological examination of the tumor biopsy concluded of glioblastoma. The surgical tumorectomy associated with chemotherapy and radiotherapy has been realized. Result is excellent because thirty months after the diagnosis, the patient is still alive with good clinical presentation (normal clinical examination) and normal CT scan control. Conclusion: Glioblastoma should be suspected in HIV infected people with neurological signs even if they are minimal; because with an early diagnosis and an adequate treatment, it is possible to increase the survival, despite the high malignancy of the glioblastoma. In Burkina Faso, the imagery should be accessible and available to the population and the medical and technical equipments should be reinforced.