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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.1, No. 4)

Publication Date:

Authors : ; ; ; ;

Page : 209-218

Keywords : Metformin; Immediate release Tablets;

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Formulate immediate release tablets of metformin to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. Immediate release tablets and Films of Metformin were designed with a view to enhance the patient compliance and provide a quick onset of action. Metformin Immediate release Tablets were prepared by direct compression method using crosspovidone, croscarmellose sodium, sodium starch glycolate a nd combinations of CP+CCS, and CP + SSG as super disintegrants Formulations F13, F14, 15 and F16 which contained increasing concentrations of combination of CP + CCS have recorded drug release 94.5%, 96.52%, 99.87% and 96.38% respectively, at the end of 25 to 30 min. Formulations F17, F18, F19 and F20 which contained increasing concentrations of combination of CP + SSG have recorded drug release 88.56%, 92.5%, 95.48% and 94.51respectivel, at the end of 30 min.

Last modified: 2014-10-15 18:00:36