A Case of Severe Hand, Foot and Mouth Disease Accompanied by Visual Field Defects in Adult Patient

Hand, foot, and mouth disease (HFMD) occurs frequently in children. Generally, most of HFMD cases are mild, while severe neurological and systemic syndromes occurred in some patients as well. This 20-year-old man from Beijing infected with HFMD and also showed the severe neuro-symptom is rarely seen before. He presented with an acute, self-limiting illness characterized by high temperature and vesical rashes eruptions on his hands, feet, and mouth. Serologic and RT-PCR tests indicated that his illness was associated with Coxsackie virus A16 (CVA16). In addition to typical clinical signs of HFMD, the patient presented with visual field defects. Notably, magnetic resonance imaging (MRI) examination indicated the lesions in his brain. In addition to the typical clinical signs, visual field defects and lesions in brain occurred in the adult with CV-A16 infection.