Design and Evaluation of Macrolide Antibiotic Ocular Films
Journal: Pakistan Journal of Pharmaceutical Research (Vol.5, No. 1)Publication Date: 2019-01-01
Authors : Nelluri.K.Durga Devi P BharghavaBhushan Rao K.Haritha K.Mrudula M.Manoj Kumar M.Jigeesha;
Page : 8-15
Keywords : Macrolide Antibiotic; Hydrophilic; ocular films; In-Vitro and Ex-Vivo;
Abstract
Azithromycin is a semi synthetic macrolide antibiotic mainly obtained from erythromycin. Oral administration of AZT is effective to treat trachoma, topical formulation is difficult to develop because of the hydrophobicity nature. The aim of present work is to formulate in the form of ocular films to treat ocular infections. AZT ocular films are formulated by using hydrophilic polymers HPMC E15, L-HPC, PG or PEG 400, gelatin and sodium alginate in different concentrations eight formulations (F1-F8) are formulated. The prepared formulations are evaluated for its thickness, folding endurance, surface texture, surface pH, moisture absorption, moisture loss, swelling index, content uniformity, in vitro and ex vivo drug release studies. Among eight formulations (F1-F8) F1 is the best formulation, which releases 71.57 % in 6hrs and it can be used to prolong the release.
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