COMPREHENSIVE ASSESSMENT OF ENDOTHELIAL DYSFUNCTION USING COMPRESSION OSCILLOMETRY AND DETERMINATION OF THE LEVEL OF ASYMMETRIC DIMETHYL ARGININE IN PATIENTS WITH BRONCHIAL ASTHMA

Aim. To study the problem of early detection of the risk of cardiovascular disease in patients with bronchial asthma by assessment of the severity of endothelial dysfunction. Materials and Methods. The study was conducted on the base of the pulmonological department of GBU RO Regional Clinical Hospital of Ryazan in 2019. All patients underwent compression oscillometry (CO) using the APCO-8-RIC apparatus, and the determination of asymmetric dimethyl arginine by ELISA method using ADMA Xpress 1 ELISA k7860 reagent kit. 40 Individuals arranged into two groups were examined: patients with the diagnosis of bronchial asthma (BA) (n=20), and the control group involving conditionally healthy individuals (n=20). Results. When comparing the main and control groups, it was found that the median asymmetric dimethyl arginine (ADMA) in the main group was 0.7 [0.5; 0.8] that was significantly higher than in the control group 0.6 [0.5; 0.6], p=0.047. According to the results of compression oscillometry, a statistically significant decrease in the diameter of the vessel in patients with bronchial asthma was found compared with the control group (p<0.001), increase in the median diastolic (p<0.009) and mean pressure (p<0.007), as well as of the minute blood volume (p<0.023). A statistically significant relationship between the duration of bronchial asthma disease and the pulse wave velocity was identified. Conclusions. The asymmetric dimethyl arginine level in patients with bronchial asthma was significantly higher than in the control group. According to the results of compression oscillometry, in patients with bronchial asthma a significant decrease in the diameter of the vessel, an increase in diastolic and average blood pressure, and in the minute blood volume were found in comparison with the control group. A statistically significant relationship was established between the duration of bronchial asthma disease and the pulse wave velocity.