The Characteristics of Blood Biochemical Parameters of Women Injured in the Presence and Absence of Chronic Alcohol Intoxication

Despite the large number of studies that examine the impact of chronic alcohol intoxication on the morphological and functional status of internal organs with mechanical trauma, including trauma of the abdomen, systematically, there have not been conducted any research with the use of a complex of modern laboratory studies. The purpose of the study was to develop a set of criteria to evaluate the effects of chronic alcohol intoxication on the morpho-functional state of the internal organs (liver and pancreas) in women with mechanical trauma biochemical blood indices. Material and methods. Research materials are medical records and patient ambulatory persons of 24 patients with chronic alcoholism, who appealed for help to the regional drug treatment clinic, patient medical records and outpatient injured 38 people who applied to hospital. We used biochemical methods: a) blood chemistry: study of total protein, alanine aminotransferase, aspartate aminotransferase, glucose, cholesterol, total, direct and indirect bilirubin, alpha -amylase, b) forensic blood chemistry, urine for alcohol content. Results and discussion. As a result, our research has established that the most likely among the best biochemical indicators to assess the functional state of the liver, which suffers the most under the influence of chronic alcohol intoxication was alaninaminotransferase, aspartataminotransferase, total and direct bilirubin, which significantly raised during abuse of alcohol. Pathology of the pancreas state studied by the enzyme α- amylase rose in alcoholic and traumatic injuries. During the study we found that the biochemical parameters of blood in women statistically significantly different between all study groups (p <0.05). The first group consisted of women who died nonviolently and had the history of chronic alcohol intoxication; the second group consisted of women who died from mechanical injury with histories of chronic alcohol intoxication; the third comprised women who died from mechanical injury. The level of total protein in the first group studied women with chronic alcohol intoxication. It was on average 70,05 ± 0,69 g/l (median, 70.0), which was not statistically different from the amount of total protein in the second studied group of women who died from injuries and patients with chronic alcohol intoxication. The third group of women died from injuries in the absence of chronic alcohol intoxication, and accordingly was on average, 70.41 ± 0.67 g/l and 69.95 ± 0,90 g/l (median 70.0). Significant differences were P1 -2=0.59, P1 -3=0.92, P2 -3=0.52. The level of alanine aminotransferase in the first group was studied in women with chronic alcohol intoxication. It was on average 9.45 ± 0.44 mmol / l (median 9.0), which was statistically significantly higher than in the second group 7.39 ± 0.28 mmol / L (median, 7.0). The third group where the content of alanine aminotransferase was on average 0.57 ± 0.03 mmol / L (median, 0.60), (P1-2 = 0.0005, P2-3 and P1-3 <0.0001). The content of aspartate aminotransferase in the first group studied in women with chronic alcohol intoxication was on average 3.84 ± 0.21 mmol/l (median 4.0) which was statistically insignificant lower than in the second group where the number of aspartate aminotransferase was on average 4.12 ± 0.19 mmol / l (median 4.0) and statistically insignificant higher than the third group, where the content of aspartate aminotransferase was on average 0.37 ± 0.02 mmol / l (median, 0.35), with a significance level of differences were as follows: P1-2 was 0.37, P2-3 and P1-3 <0.0001.