Biochemical Indices of Blood and their Diagnostic Efficacy in Experimental Models with Chronic Sinusitis of the Maxillary Sinus in Animals

Sinusitis of the maxillary sinus is one of the most frequently diagnosed diseases in maxillofacial surgery and otorhinolaryngology. The socially significant issue is that chronic odontogenic sinusitis of the maxillary sinus affects, as a rule, persons of young able-bodied and fertile age. Development of new methods of treatment and rehabilitation measures is impossible without experimental studies including those containing a biochemical component. At the same time the diagnostic efficiency of biochemical parameters of blood serum in experimental animals with the model of chronic sinusitis of the maxillary sinus has not been studied until now. The purpose of this work was to determine the changes of blood biochemical parameters (levels of total protein, the level of albumin content, the activity level of alkaline phosphatase (ALP), levels of calcium ions (Ca2+), the content of ions of phosphorus (P)) in the modeling of chronic sinusitis of the maxillary sinuses in the experimental conditions and to determine their diagnostic efficiency. Material and methods. The study was conducted on 10 male rabbits with a model of chronic sinusitis of the maxillary sinus. The above biochemical parameters were studied in the blood serum of experimental animals. The obtained data was subjected to statistical analysis using the software package "Statistiсa 10.0". Diagnostic efficiency was calculated for each of the indices. Results and discussion. The level of total protein in animals with the model of chronic sinusitis was 67.5 (64.0-71.0), the level of albumin was 56.0 (55.0-59.0). The level of activity of alkaline phosphatase was equal to 31.3 (21.1-36.8), the level of Ca2+ ions was 3.64 (3.54-3.75) and the level of the content of P of 1.17 (1.03-1.44). These changes in the biochemical indices of blood serum have significant differences, amenable to the description of Friedman's criterion which is for the presented situation χ2=7.6, p<0.05. When comparing these norms with biochemical parameters of blood serum of experimental animals with the model of chronic sinusitis of the maxillary sinus, their significant difference was revealed by Wilcoxon criterion (T=2.02, p<0.043). Conclusions. The obtained results proved that the considered biochemical parameters of blood serum have a high diagnostic efficiency and can be used both for diagnosis and for evaluation of the quality of treatment and rehabilitation measures in experimental facilities with a model of chronic sinusitis of the maxillary sinus.