Detection of Сypermethrin Residues in Toxicological Control Objects Using Gas Chromatography–Mass Spectrometry with Solid-Phase Extraction

Method for determination of synthetic pyrethroid (cypermethrin) using gas chromatography-mass spectrometry (GCMS) in the objects of toxicological control was carried out. The sample preparation via solid-phase extraction (SPE) with the increased capacity / selectivity concentration cartridges «Diapak С18 Plus» was used before GC-MS measurement. Methodological approach was used for quantitative determination of cypermethrin in food material, food end products, and tissues of animal/insect origin. The method is based on combination of GC-MS with electronic ionization (EI, 70 eV) via SPE. It is characterized by cypermethrin limit of detection (LOD) of 3 g·kg-1 and relative standard deviation (RSD) of not higher than 5 %. GC-MS sensitivity of cypermethrin quantitative determination is approached via selective ion monitoring (SIM/SIR-mode) with parameters of m/z=163 (principal ion), and m/z=181, 127, (confirmation ions) accordingly.