Electrochemical Determination of Doxorubicin in Injection Samples Using Paste Electrode Amplified with Reduced Graphene Oxide/Fe3O4 Nanocomposite and 1-Hexyl-3-methylimidazolium Hexafluorophosphate

In this study, a doxorubicin electrochemical sensor was fabricated by modification of paste electrode (PE) with reduced graphene oxide/Fe3O4 nanocomposite (rGO-Fe3O4-NC) and 1-hexyl-3-methylimidazolium hexafluorophosphate (HMIZHFP). The rGO-Fe3O4-NC/HMIZHFP/PE was shown to have good catalytic effect for oxidation of doxorubicin in aqueous solution and oxidation current of anticancer drug was improved about 2.76 times. In addition, oxidation of doxorubicin was shown in a linear dynamic range 3.0 nM-280 µM with detection limit 1.0 nM at surface of rGO-Fe3O4-NC/HMIZHFP/PE. The recovery data 99.33-103.7 % was calculated for measurement of doxorubicin in injection and pharmaceutical serum using rGO-Fe3O4-NC/HMIZHFP/PE as sensor that is acceptable for a new analytical sensor.