Application of Z-score LORETA Neuro-feedback in Therapy of Epilepsy

Unfortunately despite major progress in the treatment of epilepsy approximately 30% of patients are still refractory to medical therapy. Surgical treatment may be an option for some of those patients, however many may not be interested or eligible. There is a demand to develop alternative treatments which would offer substantial reduction of seizures and improve quality of life. Currently a mainstay of therapy in epilepsy is pharmacological. Multiple medications are available on the market for different types of epilepsy. Some of these are broad-spectrum medications which cover both primary generalized and secondary generalized epilepsy. Other relatively narrow spectrum medications are effective mostly for certain types of epilepsy. The patients with epilepsy who do not respond to pharmacological treatment are classified as medically refractory. In these cases other forms of therapy need to be applied in order to reduce frequency of seizures. In the pediatric population the ketogenic diet has been found to be effective in reducing seizure numbers in selected patients [1]. Surgical options include minor surgery such as vagus nerve stimulator implantation [2], or major surgery including lesion resection [3].