CONVENTIONAL AND MICROWAVE SYNTHESIS and ANTIOXIDANT EVALUATION OF BENZOTHIAZOLE SUBSTITUTED 4-THIAZOLIDINONES
Journal: Indian Drugs (Vol.57, No. 10)Publication Date: 2021-01-29
Authors : Shetty Chaithra R; Bhat Ishwar K; Kumar Abhishek; Merugumolu Vijay Kumar; BC Revanasidappa; Gatphoh Banylla Felicity Dkhar;
Page : 17-22
Keywords : For Correspondence: E-mail: bhatishwark@nitte.edu.in;
Abstract
Antioxidants exert their action chiefly in controlling and preventing the free-radicals and their reactions and thus it has a vital role as health protecting factor. There are many scientific data proposing that antioxidants lower the threats of some chronic diseases including cancer and heart disease. In the present work, the hybrid molecule i.e benzothiazole substituted 4-thiazolidinone, has been taken for the study and different novel benzothiazole substituted 4-thiazolidinone derivatives were synthesized by reacting 2-amino-6-methyl benzothiazole with aromatic aldehydes in alcohol media. The resulting Schiff bases were made to react with thioglycolic acid in dioxane. Characterization of synthesized compounds was done by IR, 1 H NMR and Mass spectroscopy. The same reaction was performed in the microwave assisted reaction condition and compared with conventional synthesis. In vitro antioxidant activities of compounds were performed by three different methods, out of which Compound TZ4 emerged as a promising molecule.
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