Evaluation of the Anti-hyperglycemic Activity of Three Medicinal Plants Extracts in Agadir Region (South of Morocco)

Our study was carried out to evaluate the hypoglycaemic and antidiabectic activity of organic extracts of three plants: Argania spinosa (leaves), Ceratonia siliqua (aerial part) and Pistacia atlantica (leaves), traditionally used in herbal medicine in Agadir region. Oral administration of extracts was tested at 50, 150 and 250 mg/kg and the anti-diabetic effect was studied by inducing diabetes by pancreatectomy and by alloxan injected at a dose of 180 mg/kg. Ehanolic extract of Argania spinosa induced a significant transient hypoglycemia with a maximum reduction of 12% for the concentration 250 mg/kg compared to the control. Analyses of the hypoglycemic activity show a very highly significant effect for extracts of Argania spinosa and Ceratonia siliqua at the two concentrations tested (250 and 150 mg/kg). On the other hand, the extract of Pistachia atlantica did not show any remarkable results. In the same sense, the results of the anti-hyperglycemic activity showed a remarkable activity for the extract of Argania spinosa and Ceratonia siliqua and a slight activity for Pistachia atlantica.