Formulation and IN-VITRO Evaluation of Losartan Potassium Sustained Release Matrix Tablets

The objective of the present study was to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different polymer such as Hydrophilic polymer HPMC and natural polymers like xanthan Gum and (XG), guar gum., in different ratios. All the formulations were analysed by measuring different parameters: hardness, consistent weight uniformity friability assay and in-vitro drug release and tested for the physiochemical equivalence of tablets through the evaluation of both official and non-official standers to check if they comply with specification of USP. The in-vitro drug release kinetics of drug was studied by using Zero order, First order, Higuchi, and Korsemeyer-peppas models based on the correlation coefficient (r2) value. The formulations F2, F3, F4, F5 and F8 showed compliance with USP Requirement and FDA Guideline. This Formulation showed acceptable tablet properties and in vitro drug release. The resulting formulations produced matrix tablets with optimum hardness, consistent weight uniformity friability and assay. All tablets but five formulation exhibited gradual and near completion sustained release for losartan potassium and Not less than 70% released at the end of 10hrs. The results of dissolution studies indicated that five formulations (F2, F3, F4, F5 and F8) are the most successful of the study and exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing polymer percentage.