CORRELATION OF CREATINE KINASE AND MYOGLOBIN CONCENTRATIONS IN PATIENTS SUFFERING FROM DEBILITATED CONDITIONS RELATED TO MYOPATHIES

The present study describes the determination of a possible correlation between CK and myoglobin levels, in addition to the hypothesis that increase in myoglobin concentrations may precede changes in CK levels in patients suffering from myopathies. The inclusion period for this cohort study was from December 2005 to December 2007. Patients who met the laid down and referred criteria were eligible for the study, which includes patients aged > 20 years to < 75 years (both gender) and had a diagnosis of myopathies as per description. Standard protocols were followed for blood samples collection and estimation of aldolase, CK AST, ALT, CK and myoglobin levels. Regression correlations were determined and results were compared as per R2 and significance level P < 0.05. A total of 48 patients were included in the study, males = 32 (66.66%) and females = 16 (33.33%). Except for both CK and myoglobin, the rest of the enzymatic components were not found to be linearly correlated showing R2 factor less than 0.0012. Notably CK and myoglobin levels, when plotted through regression, were leading with exceptional correlation, with R2 0.491 for total patients, R2 0.512 for males and 0.532 for females. It was suggested that by combining both CK and myoglobin estimation in patients with myopathies especially dermatomyositis or polymyositis, it provides better overall impression of muscle damage and related conditions. Correlation of CK and Mb levels in myopathies.