Plasma Uric Acid Level and its Association with Type II Diabetes Mellitus

Introduction: Hyperinsulinemia as a consequence of insulin resistance causes an increase in serum uric acid (SUA) concentration by both reducing renal uric acid secretion and accumulating substrates for uric acid production. Therefore, it remains controversial whether SUA is independently associated with the development of type 2 diabetes. Aim: Plasma uric acid level and its association with Diabetes Mellitus II. Method: Analytical case control study with 145 cases and controls with uric acid level and blood sugar levels and duration of Diabetes. Result: baseline parameters of the study population with the studied cases were overweight with uncontrolled Diabetes Mellitus II. As compared to controls the cases had high Glycosylated Hemoglobin levels and raised mean serum uric acid levels. Diabetic cases ~27% had high uric acid levels as compared to controls. None of the cases in control group had raised serum uric acid levels. Duration of Diabetes has a direct relationship with the levels of raised uric acid. Conclusion: Serum uric acid levels were significantly elevated in Diabetic population. Significant positive correlation between serum uric acid levels and duration of Diabetes Mellitus II was seen.