Review On - Therapeutic Efficacy of Secondary Metabolites Extracted from Marine Algae Associated Endophytic Fungi

Drug resistant are high in country especially cancer and infected diseases therefore, there is a need to search new ecological niches for potential sources of natural bioactive agents for different pharmaceutical, agriculture, and industrial applications. Cancer is a major health problem due to its high rate of morbidity and mortality. Severe side effects are associated with most of the available anti-cancer drugs; hence we are focusing on natural compounds with minimal toxicity. Endophytic fungi that are residing a symptomatically in internal tissues of all higher plants are of growing interest as promising sources of biologically and pharmacologically active agents and bio-active molecules. Especially marine endophytic fungi have the ability to synthesize novel metabolites due to its high salinity, high stress and unexplored marine environmental status. The marine environment is home to an immensely vast and complex array of species and ecosystems, most of which remain undiscovered. This does not come as a surprise, considering that the ocean covers approximately 70 % of the planet’s surface. Enumerate a total of approximately 226.000 described marine eukaryotic species, and estimate that one-third to two-thirds of marine species are yet to describe. Natural compounds are the main source of active ingredients in medicines, Indeed, the discovery of natural products in terrestrial fauna and flora has produced a grand diversity of bioactive compounds with the most varied chemistry and effects, as diverse as anticancer, anti-inflammatory, anti-parasitic, antiviral, analgesic, immuno-modulator, anti-diabetic activity, among many others.