Antiplasmodial and Toxicological Effects of Carica papaya and Allium sativum on Albino Rats Infected with Plasmodium berghei
Journal: International Journal of Science and Research (IJSR) (Vol.8, No. 5)Publication Date: 2019-05-05
Authors : Okolie N.J.C; Obiajunwa Kelechi Olivia;
Page : 1764-1769
Keywords : Toxicological; antiplasmodial; Carica papaya; Allium sativum Plasmodium berghei;
Abstract
Malaria is still one of the greatest global public health problems especially in sub Saharan Africa. The aim of this study is to evaluate the anti-plasmodial and toxicological effects of the ethanolic extracts of Carica papaya and Allium sativum using an in vivo animal model. Malaria infection in rat was initiated by intraperitoneal (IP) inoculation of 0.5 ml blood, diluted to contain 2 x 107/ml parasitized red blood cells from a donor mouse infected with P. berghei for four days. Three control groups were created viz: non-inoculated, inoculated but untreated and standard control (inoculated and treated with 10mg/kg Combisunate). Experimental groups consists of two categories with five sub-groups were created with each category representing the ethanolic extracts of Carica papaya and Allium sativum respectively. The five sub-groups in each category represent the five concentrations of 100, 300, 500, 800 and 1000mg/kg administered for five days of treatment. The average suppressive effects were obtained. Result showed that the parasitemia level for the treated groups decreased progressively for the five days period. The result of the biochemical markers showed that the plant extracts posed no toxicity effects. Hence, the ethanolic extracts of Carica papaya leaves and Allium sativum bulbs showed moderate anti-plasmodial properties and are less toxic to the body.
Other Latest Articles
- To Study the Impact of Homeschooling on Students Achievements - A Simple Literature Review
- The Effect of Blood Pressure Risk Factors (Packed Cell Volume and Body Mass Index) on the Incidence of Hypertension
- Mixture Model of Different Distributions: A Simulation Study with Different Censoring and Mixing Probabilities
- Evaluate the Efficacy of Metformin and Glimepiride with Metformin in Patients with Type II Diabetes Mellitus
- Flow of Non-Newtonian Fluid between Two Parallel Plates Due to a Suddenly Moved Plate
Last modified: 2021-06-28 18:12:38