Toxicological and Antiplasmodial Activities of Ethanolic Extracts of Mango (Mangiferaindica) Leaves and Bitter Cola (Garcinia kola) Seeds in Albino Rats

Malaria is one of the most important diseases in the world. The choice for the treatment is highly limited due to drug resistance. Hence, finding the new compounds to treat malaria is urgently needed. The present study aim at investigating the toxicological and anti-plasmodial effects of extracts of Mangifera indica and Garcinia kola on Albino rat infected with Plasmodium berghei. For efficacy test in vivo, standard 5-day suppressive test was carried out. Rats were inoculated with 107/ml parasitized erythrocytes of P. berghei by intraperitoneal injection. The extracts (100, 300, 500, 800, and 1000mg/kg) of each plants were given separately to each group and orally once a day for 5 consecutive days. Percentage of inhibition, and biochemical indices were estimated. Combisunate (10mg/kg) was given to infected rats as reference control while untreated control was given only distilled water. It was found that ethanolic extracts of Mangifera indica and Garcinia kola at different doses showed dose dependent parasitemia inhibition. Therefore, Mangifera indica and Garcinia kola exact significant anti-plasmodial activity and prolonged survival time with no toxicity.