A Review on Pharmaceutical Mini-Tablets

The objective of controlled drug delivery systems is to deliver the drug over an extended period of time or at a specific duration during the treatment. Oral controlled release drug delivery systems are available as single unit dosage forms (SUDFs) or multiple unit dosage forms (MUDFs). Multiple unit dosage forms are based on subunits such as pellets, granules, or mini tablets. Among all MUDFs, mini tablets represent a new trend in solid dosage form design, with the main aim of overcoming drug-excipients or drug-drug interactions. They also offer an alternative for pellets and granules because of their relative ease of manufacturing and dosage forms of equal dimensions, weight with smooth regular surface can be produced in a reproducible and continuous way. They do not require for any solvent for their production as a result problems with stability can be avoided, they also require less coating material and also there is a great flexibility in formulation development. This review is focus on various aspects of mini tablets.