A Study on Use of Two Doses of Mifepristone Followed by Misoprostol in Pregnancies with Intrauterine Foetal Death in Mid and Late Trimester

Objective: To assess the efficacy, safety and acceptability of this new regimen for induction of labour in IUFD in mid and late trimester pregnancies. Design: Observational study Setting: Umaid Hospital Jodhpur (Rajasthan, India) Methods: A total of 100 women with IUFD of gestational age more than 12 weeks were studied. Once the termination of pregnancy was decided, Tab. Mifepristone 200mg was administered per orally followed again by Tab. Mifepristone 200mg 24 hours later, regardless of gravid status and mode of previous deliveries.48 hours after the second dose of Tab. Mifepristone, Tab Misoprostol was administered per vaginally. For gestational age less than 28 weeks 200mg Misoprostol PV every 4 hours ( maximum 4 doses), and for gestational age more than 28 weeks 25mg Misoprostol PV every 4 hours ( maximum 4 doses).