Transrectal Ultrasound Guided Biopsy of Prostate in Patients with Raised Serum Prostate Specific Antigen - A Histopathological Study

Introduction Transrectal ultrasound (TRUS) -guided needle biopsy of prostate is considered gold standard for the diagnosis of prostatic cancer. Objectives of the study To determine the spectrum of pathological lesions in TRUS-guided needle biopsies of prostate in men with increased serum prostatic specific antigen (PSA). Materials& methods A prospective study carried out at the Department of Urology, Government Royapettah Hospital from May 2014 to July 2016.100 men underwent TRUSguided prostate biopsies for suspected prostate cancer. In most cases, 12 cores were taken. Each core was processed with routine paraffin method and stained with standard hematoxylin& eosin stain and for reporting of malignant cases Gleason& #039, s grade and score was used. Results The mean age of patients was 669 years (range 57-78 years). The mean serum PSA was 13.611.2 ng/ml. In present study, 75 (75 %) cases showed benign lesions and 25 (25 %) were malignant. Benign lesions consisted of benign prostatic hyperplasia.46 of benign cases (46 %) showed significant inflammatory changes. Among malignant lesions, most were of moderate to high Gleason grades and scores. Conclusions The detection rate of prostate cancer rises with an increase in serum PSA level.