Surgical Outcomes of Non Descemet's Stripping Endothelial Keratoplasty: Analysis of 100 Consecutive Cases

Purpose To analyze the surgical outcome of Non-Descemets stripping endothelial keratoplasty (DSEK) in 100 consecutive cases performed by a single surgeon at tertiary eye hospital. Study design A prospective, non randomized, non-comparative surgical case series Methods A prospective, non randomized, non-comparative surgical case series in which first consecutive 100 patients (age 18 years and BCVA 20/400) with endothelial dysfunction underwent non stripping descemets membrane endothelial keratoplasty (Non-DSEK). The patients were followed up for a period of 1 year at regular intervals. The best corrected visual acuity (BCVA), refractive and keratometric astigmatism, endothelial cell density, graft rejections and failure, dislocation of graft and other complication like secondary glaucoma were evaluated for 1 year after surgery. Results Hundred eyes of hundred consecutive patients included in this study were analyzed. There were 54 males and 46 females with a mean age of 58.69 10.2 years (range 18 to 82 years). Indications of the surgery were pseudophakic bullous keratopathy (70 eyes, 70 %), Fuchs dystrophy (14 eyes, 14 %), aphakic bullous keratopathy (5 eyes, 5 %). After three months, 78 % (n=78/100) patients recovered from corneal endothelial dysfunction and regained 20/60 or better vision with best available refractive correction. At three months follow up, mean endothelial cell density was 1554 +/-160 cells/mm2 with mean endothelial cell loss was 33+/-4 %. Graft dislocation in 12 eyes which were managed by rebubbling. However, Graft rejection was seen in 4 eyes (4 %) Conclusions Non DSEK provides rapid visual recovery and it is a safe and effective technique to restore corneal endothelial dysfunction