Assessment of the Genotoxic Effect Caused by Herbal and Synthetic Toothpaste

The purpose of the paper is to highlight the advantages of using the herbal tooth paste over synthetic toothpaste and to identify if there is any significant difference between the varieties of herbal toothpaste with ingredients such as Anacyclus pyrethrum, Azadirachta Indica, Xanthoxylum alatum, Mentha spicata, Syzygium aromaticum, Piper sylvaticum, Barleria prionitis, Curcuma longa, Salvadora persica, Quercus infectoria. These herbal mixture acts as antioxidants which may protect the cell against genetic metabolic damages. The study is carried out on micronuclei. We have carried out the study on women population.52 subjects of age ranging from 17 to 20 years were included. Paired t-test has been carried out to know whether there is any significant difference in presence of micronuclei due to herbal and synthetic toothpaste in the subject. The results show that herbal toothpaste has significantly lower number of micronuclei compared to synthetic toothpaste which represent nuclear DNA damages; the comparison was made for the number of micronuclei between herbal and synthetic toothpaste since the number of micronuclei is a discrete reflection of nuclear DNA damage. To identify if there is any significant difference in the range of micronuclei between the varieties of herbal toothpaste, Chi-square test for independence of attributes has been performed and it was found that there is no significant difference between varieties of herbal toothpaste.