Effect of Electroacupuncture on Anovulation, Epinephrine and Norepinephrine Levels in Drug Induced Polycystic Ovary Rats

Background Earlier studies on the effect of constant electro-acupuncture (EA) treatments in rats with drug-induced polycystic ovary syndrome (PCOS), has been shown to revise the hormones and neurotransmitter levels. Aim The present study was conducted with the aim to test the hypothesis that repeated EA treatment modulates Epinephrine (EPI) and Norepinephrine (NE) level of PCOS and anovulation. Method This was done by analyzing EPI and NE level using high-performance liquid chromatography (HPLC) in plasma of normal rats (n=10), drug Estradiol- Valerate (EV) induced PCOS rats (n=10) and PCOS rats treated with EA (n=10) and modulation of ovulation was studied by staining the ovary. Result The present study shows the concentration of EPI and NE level in the plasma was significantly (Pless than 0.001) lower and reversal of ovulation from anovulation in the PCOS rats treated with EA compared with the EA untreated PCOS rats. Conclusion The EA treatment reverses the EPI and NE level indicate that PCOS modulates the sympathetic activity of rats and the EA treatment could bring back the Neuroendocrinological state and the sympathetic activity of PCOS rats which turn induce the ovulation back to normal.