Measuring Tolerance Dose of the Methotrexate for Induction of Oral Mucositis in Dark a Gourti Rat.(Pilot Study)

Oral mucositis severe side effect, caused by treatment with radiotherapy and chemotherapy (CT) for cancer. Major progress has been made in recent years in understanding the mechanisms of oral and enteral mucositis. This progress is largely due to the development of representative laboratory animal models of mucositis. A total of sixteen rats were included in this study and divided into three groups: group (A) included five rats, group (B) included six rats and group (C) included five rats. group A were injected with a dose of 80mg/kg methotrexate (MTX) cytotoxic drug with a single intraperitoneal (I. P) injection at base line time (day zero). Group (B) were injected with a dose of 60 mg/kg MTX (I. P) at day zero, group (C) the rats were injected with a dose of 40mg/kg MTX at day zero. There was a statistical significant negative correlation that correlates the doss of MTX with the mortality duration of rats among the plot experimental study groups. We found all rats induced with oral mucositis at day seven with the main scores range (0-2); The rats had died 21 days after treatment.