Hyperglycosylated hCG in a Group of Iraqi Patients with Gestational Trophoblastic Disease

Background Hyperglycosylated hCG a newly discovered variant of hCG which can be used as a predictor of invasion of trophoblastic cells in patient with gestational trophoblastic disease. Objectives To measure hyperglycosylated human chorionic gonadotrophin and to assess how far it can be used as predictor of invasion in invasive mole and choriocarcinoma. Study design Case-control study. Setting Gynecological department in Baghdad Teaching Hospital from January 2016 to January 2017. Patient and Methods 60 women were enrolled in this study 30 of them were with gestational trophoblastic disease (no. = 30) the remainder were normal pregnancy (no. =30), hCG H level was measured in both groups. Results Mean serum hCG-H level was significantly higher in patients with gestational trophoblastic disease compared to control women ( 460.5 168.35, 206.8 19.99) respectively with p value less than 0.05. Mean serum hCG-H level was significantly higher in patients with gestational trophoblastic disease Invasive mole and chriocarcinoma compared to patient with molar pregnancy. Before evacuation (772.11 184.08, 398.27 65.86). After evacuation (550.52 146.15, 340.40 85.61). With p value less than 0.05. Conclusion 1- Serum hCG-H level was higher in patients who had invasive mole and patients with choriocarcinoma than patients with gestational trophoblastic disease, so it can be used as a predictor of invasion in patients with invasive mole and choriocarcinoma.2- Serum hCG-H level can be used in patient with abnormal - hCG after evacuation when it is slowly decreasing or plateau.3-It is better to measure the ratio hCG-H/total hCG and using uniform method test and units so we can understand the actual changes that happen in invasion.