The Significance of CXCL10 and CXCL16 in Serum and Placenta of Toxoplasmosis - Induced Abortion

The level of CXCL10and CXCL16 was determined in sera and placenta homogenate of toxoplasmosis-induced abortion (25 cases), in addition to 25 cases of accidental abortion. Twenty-five healthy control women were also included for comparison of serum level. CXCL10 level was significantly increased in serum (39.99 ? 1.96 pg/ml) and placenta homogenate (36.35 ? 1.27 pg/ml) of toxoplasmosis-induced]'/. , abortion patients, as well as accidental abortion patients (42.27 ? 0.98 and 35.54 ? 1.40 pg/ml, respectively) compared to control serum level (29.66 ? 2.03 pg/ml), while the increases can be more pronounced in serum. For CXCL16 showed a similar pattern of increased level. These results suggest that systemic production of CXCL10, CXCL16 play a significant role in inducing of abortion in toxoplasmosis patients.