Study of Brain Morphology in Healthy Aging and Alzheimer Disease in Sudan using MRI

This study was done in Sudan University of science and technology and Department of Diagnostic Radiology, Khartoum state Hospitals, - Khartoum, Sudan, during the period from April 2015 to June 2017. This study included two groups. Group (A) were 100 healthy individuals, (66 males (66%), 33 females (44%). . Group (B) 300 patients, 198 male (66. %) And 102 females (44.0%). with high probability of AD. The mean age of all patients is 45years ranging (15-75) years additional to control group. MRS studies were performed on 1.5 Tesla Toshiba Exclelart Vantage whole body MR systems using standard imaging head coil. The results of this study revealed that the most affected patients by Alzheimer's disease (AD) were male 202 (67%), their ages above 7th decay, the most common sign is Apraxia (77%) and Amnesia (76%). And this study revealed that Predemntia is most type affected by patients (35%) (72 male, 35 female). The majority of patients diagnosed in moderate stage of AD. Early stage of Alzheimer's disease (AD) is rarely affected by patients or rarely diagnosed because with hidden signs and symptoms. The causes the Alzheimer's disease (AD) in this study as the following the most cause of AD is Genetic factor 44% (80male, 52 females), Amyloid Hypothesis factor is 43 % ( 78male, 52 females) and rare cause factor is Tau Hypothesis 07 % ( 15 male, 06 females). Diagnostic Imaging Factors the Alzheimer's disease revealed that the Hypocampal Atrophy imaging factor is most predictive factors in diagnosis by Magnetic Resonance Imaging (MRI) (71%), Temporal lobe atrophy (MTA) factor (71%), Diffuse cerebral Atrophy factor is (68%) and Increase size of Ventricles factor (66%). This study concluded that the majority of patients were male, the most common sign is Apraxia, the majority of patients diagnosed in moderate stage of AD, the most cause of is Genetic factor and the Hypocampal Atrophy imaging factor is most predictive factors in diagnosis by Magnetic Resonance Imaging (MRI.