ESTIMATION OF MONTELUKAST SODIUM AND FEXOFENADINE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY Q-ABSORBANCE METHOD

A simple precise, accurate, cost effective method has been developed for the estimation of Montelukast sodium and Fexofenadine hydrochloride in combined tablet dosage form by Q-absorbance method. The isobestic point was found at 226 nm. The developed method showed linearity in the range of 5-25 ?g/ml for both drugs. LOD and LOQ values were found to be 2.3 ?g/ml and 3.45 ?g/ml for Montelukast sodium and 2.67 ?g/ml and 3.35 ?g/ml for Fexofenadine hydrochloride respectively. The % RSD values were within the acceptable range. The developed method has been validated as per ICH guidelines.