The Distinct Pattern of DIC among the Patients with Dengue Virus Infection, Red Sea State, Sudan

The clinical spectrum of dengue fever (DF) varies from acute febrile course to refractory shock and bleeding with increase mortality. Disseminated intravascular coagulation (DIC) is the most serious mechanism involved in the pathogenesis of bleeding. A case control study was conducted to detect the DIC in dengue infection in Red Sea State. Platelet count, Coagulation tests and D-Dimer were sequentially measured. Out of 334 patients with dengue virus infection, 101 (30.2 %) had DIC. DIC was significantly higher in DF 81 (80.2 %) than in dengue hemorrhagic fever (DHF) 20 (19.8 %) of patients.56.4 % diagnosed as non-overt DIC, and 43.6 % diagnosed as overt DIC. Nearly one-third of patients had DIC. Non-overt DIC was the distinct pattern present in the study. D-Dimer is a marker for DIC may predict the clinical course of the disease.