Synthesis, Characterization and Antifungal Activity of Some Organotin (IV) Derivatives of Octanedioic Acid

Four organotin (IV) derivatives of octanedioic acid potassium dibutyltin (IV) octanedioate, potassium tributyltin (IV) octanedioate, potassium diphenyltin (IV) octanedioate and potassium triphenyltin (IV) octanedioate were synthesized by reacting octanedioic acid with potassium hydroxide to give the potassium hydrogen salt followed by reaction between the salt and an organotin oxide/hydroxide to give the potassium organotin dicarboxylates. The compounds were characterized by tin content analysis, FTIR, 1H NMR and 13C NMR and tested for antifungal activity against four strains of Microsporum spp and two strains of Trichoephyton spp. Result showed that the compounds synthesized in general exhibited greater fungitoxicity than the Organotin oxides, organotin hydroxide, potassium hydrogen octanedioate and octanedioc acid. Organotin moieties are known to play a vital role in deciding the antifungal activity of an organotin compound, this is true in this work as the order of antifungal activity was potassium triphenyltin (IV) octanedioate greater than potassium tributyltin (IV) octanedioate greater than potassium dibutyltin (IV) octanedioate greater than potassium diphenyltin (IV) octanedioate.