Relation of Parkinson's Disease to Rhabdomyolysis: an Overview

Parkinson-s disease (PD) is neurological disorder developed due to hyposecretion of dopamine, a neurotransmitter released by nerve cells to send signals to other nerve cells. There is loss of dopamine generating cells leading to the formation of lewy bodies inside the neurons. This leads to many motor and non-motor dysfunctions. Movement of individuals is mostly affected. Levodopa treatment has been normally employed to maintain the dopamine levels to reduce symptoms of PD. However, long term use of levodopa for treatment of PD leads to levodopa-induced dyskinesias (LID) finally leading to rhabdomyolysis. Rhabdomyolysis is a life-threatening condition caused by breakdown of muscles. This may lead to many other complications and finally acute renal failure.