Assessment of Serum Luteinizing hormone and Insulin Level of Polycystic Ovary Syndrome Women

Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy that affects women. It has been one of a major public health problem in Sudan that leads to medical consequences, it causes multifactorial in etiology such as menstrual dysfunction, hyperandrogenism, hirsutism, insulin resistance (IR), dyslipidemia and obesity which increased risk of diabetes mellitus and cardiovascular disease. Itknow that if patients with PCOS are screened for these diseases, many long-term complications can be prevented. Objective The present study was designed to assess serum luteinizing hormone andinsulin in PCOS Sudanese women and to compare them with healthy women as controls. Materials and Methods This study was a descriptive, analytic, cross- sectional and hospital-based study, carried in Khartoum- State- Sudan, it was carried out in March 2013 to May 2014.200 women with PCOS were enrolled in this study, they compared with 100 healthy women as control group, all of them were age-and weight-matched, Samples were taken after overnight fasting, then serum luteinizing hormone and insulin levels were analyzed using ELISA technique. Data management and analysis was done by using Microsoft excel and SPSS software, version 20.00. Results The patients with PCOS, having a mean age of 29.61 5.4 years and mean age 31.234.93 years of control group, were included in the study, in PCOS group the (mean SD) of serum luteinizing hormone and insulin were 11.066.21 IU/ml, 14.609.80 ng/ml, respectively while that of control group, the (mean SD) of serum luteinizing hormone and insulin were 7.003.36 ng/ml, 4.521.60 IU/ml respectively. There was statistically significant increased levels of serum luteinizing hormone and insulin in PCOS group when compared to the control group (Pless than0.05). Conclusion It concluded that there was significantly higher fasting luteinizing hormone and seruminsulin, there was significant correlation between serum luteinizing hormone, serum insulin and BMI in the study group.