Evaluation of Adenanthera pavonina Bark Extracts for Antioxidant Activity and Cytotoxicity against Cancer Cell Lines
Journal: International Journal of Science and Research (IJSR) (Vol.4, No. 12)Publication Date: 2015-12-05
Authors : Renilda Sophy A. J.; Albin T. Fleming;
Page : 48-51
Keywords : Extracts; anti-tumor; cell lines; antioxidant; cytotoxicity;
Abstract
Plant materials were used for the treatment of malignant diseases for centuries. Various studies on plant extract which have a suitable history of use in folklore for the treatment of cancer had often resulted in the isolation of principles with anti-tumour activity. In the present study, the anti-proliferative effect of acetone and methanol bark extracts of Adenanthera pavonina on three cancer cell lines using sulforhodamine-B assay and their antioxidant activities using 1-diphenyl-2-picrylhydazyl radical and its reducing ability were investigated. NCI-H460, U251, and MCF7 cancer cell lines were used in this assay. The GI50 value of methanol extract showed a lowest value of 27g/mL against NCI-H460. The antioxidant and the reducing power assay showed a significant dose dependant activity. The study also suggests that antioxidant activity of these extracts might be one of the reasons for the anticancer potential of the extracts.
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