Analytical and Antibacterial Studies of Mn (II), Co (II) and Ni (II) Complexes

The ligands possess anti-bacterial, anti-fungal, anti-inflammatory, anti-diabetic, anti-tumor, anti-proliferative, anti-cancer, anti-malarial, anti- inflammatory, herbicidal, medicinal properties. The chelating ligands act as more active agents than non-chelating ligands. Benzaldehyde and substituted benzaldehydes react with hydroxyl amine, semicarbazide, hydrazine etc. to give derivatives like oximes, semicarbazones, and hydrazones which act as good chelating ligands. These derivatives have long been prepared and analyzed by chemists for anti-bacterial, anti-fungal, anti-tubercular, anti-inflammatory, anti-diabetic, anti-tumor, anti-proliferative, anti-cancer, anti-malarial and analgesic activities. The ligands which are active against micro-organisms like bacteria, fungi, or virus are finding importance in pharmaceutical chemistry. When the chelating ligands are complexed with the metal ions their activities may alter. In view of these facts here we have undertaken the screening of metal complexes formed by combination of metals Mn (II), Co (II) and Ni (II) with ligands 2-pyrazinoyl hydrazide and its derivatives with various aromatic and heterocyclic aldehydes against various bacteria. The present paper deals with the characterization and screening of metal-complexes of hydrazones derivatives of 2-pyrazinoyl hydrazide with various aromatic and heterocyclic aldehydes such as benzaldehyde, anisaldehyde, 4-hydroxy-3-methoxy benzaldehyde, p- (N, N-diethyl amino) benzaldehyde, cinnamaldehyde, 4-methyl salicyldehyde and 2-furfuraldehyde against some gram (+ve) and gram (ve) bacteria.