A SEARCH FOR GENETIC MARKERS OF INCREASED PREDISPOSITION TO ACUTE RESPIRATORY DISEASES AND DEVELOPMENT OF THE BRONCHOOBSTRUCTIVE CONDITIONS IN CHILDREN

The article is devoted to the problem of searching for genetic markers of increased susceptibility to acute respiratory infections and the development of broncho-obstructive conditions in children that may eventually result in asthma and significant disability. As clinical and experimental studies of recent 10 years have shown, there is a close relationship between frequency of acute respiratory infections in children and development of bronchial obstruction syndrome and the genotype. This opens up a new priority direction in medical science - establishing molecular genetic markers of increased susceptibility to certain socially important diseases, the pathology of the respiratory system in particular. Aim. To establish effective molecular genetic markers of increased susceptibility of children to frequent acute respiratory diseases and bronchial obstruction syndrome. Results and Discussion. The article reviews data on the frequency of acute respiratory infections and occurrence of complications in the form of bronchial obstruction syndrome in children. An immediate need to find markers to be used for determining a high risk of frequent acute respiratory diseases and more severe and protracted course of bronchial obstructive syndrome with a need for long and expensive as treatment is demonstrated. These may be the molecular genetic susceptibility markers of a child's body to the pathology of the respiratory system. Knowledge of the genetic determinants of individual susceptibility to frequent acute respiratory diseases and bronchial obstruction syndrome in children will contribute to establishing of individual treatment and prevention strategies in these diseases. Conclusions. The review of literature devoted to the problem of determining genetic markers of increased susceptibility to acute respiratory infections and the formation of obstructive conditions in children allows to state that informative molecular genetic markers of increased genetic susceptibility of children to acute respiratory infections.