A Review on Estimation of Etoricoxib and Paracetamol in Pharmaceutical Dosage Form

Non Steroidal anti inflammatory drugs deals with complains of pain. It works pharmacologically to inhibit the prostaglandin and be able to reduce pain, fever with inflammation and that is accompanied by other pain disorders. The use of NSAIDs is very effective for reducing pain symptomatically, most widely prescribed and are the first choice in the treatment of inflammatory pain. There are various types of NSAIDs that are known, such as aspirin, paracetamol, ibufrofen, mefenamic acid, indomethacin, diclofenac, piroxicam and nimesulide. From various kinds of NSAIDs, each has advantages and disadvantages that are seen in the therapeutic effect and the side effects caused. Therapeutic effects related to the mechanism of action of this preparation. The use of NSAIDs in children really needs attention. Nonsteroidal anti inflammatory drugs NSAIDs are among the most frequently prescribed drugs worldwide and are used for relief of inflammatory, chronic e.g., rheumatoid arthritis, osteoarthritis, and gout , and acute e.g., headache, postoperative pain, and orthopedic fractures pain conditions 1 . NSAIDs formulations are also available as over the counter pharmaceutical preparations. The anti inflammatory activity of NSAIDs and most of their other pharmacological effects are related to the inhibition of the conversion of arachidonic acid to prostaglandins, which are mediators of the inflammatory process. NSAIDs are potent inhibitors of cyclooxygenase in vitro and in vivo, thereby decreasing the synthesis of prostaglandins, prostacyclin, and thromboxane products . The growing demand for NSAIDs stimulates higher level of quality control of these therapeutic substances and preparations. Hence, there is need to develop new analytical methods for qualitative and quantitative analysis of NSAIDs and their combination drugs.Etoricoxib 1 , 5 chloro 2 6 methyl pyridine 3 yl 3 4 methylsulfonyl phenyl pyridine , is a relatively new non steroidal anti inflammatory drug with high selectivity in cyclooxygenase 2 inhibitory activity. It is indicated to relieve the signs and symptoms of osteoarthritis, ankylosing spondylitis and acute gouty arthritis. Miss. Poonam Harish Chaure | Prof. Satish Shelke | Dr. Shrish P. Jain "A Review on Estimation of Etoricoxib and Paracetamol in Pharmaceutical Dosage Form" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45099.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/45099/a-review-on-estimation-of-etoricoxib-and-paracetamol-in-pharmaceutical-dosage-form/miss-poonam-harish-chaure