Impact of Social Isolation on Serum Sodium and Cortisol Level in male Wistar Rats

Background Aim Loneliness due to social isolation is a source of psychological stress in adults. This study evaluated the impact of social Isolation on serum sodium and cortisol level in male wistar ratsMethods Sixteen male wistar rats were randomly divided into two groups n = 8 , Group 1 served as control. And were socially housed. Group 2 consisted of eight individually caged Wistar rats. The animals had access to food and water ad libitum and their level of physical activity was observed. After six weeks of Isolation, blood was collected from the animals via ocular puncture for Serum Cortisol and Sodium ion analysis, all data was analysed using SPSS software version 25.0. Values were considered significant at P 0.05.Results Results showed significant increase in the mean cortisol 33.82 ± 1.17 , decrease in mean sodium ion 113.875 ± 5.24 and negative correlation between sodium and cortisol.Conclusion The results from this study have shown that social isolation is a source of psychological stress which leads to depression and hyponatraemia. Uzoma Reichmann Iheanyi | Ufearo Chibueze Steven | Njoku-Oji Nancy Njideka | Okonkwo Chukwudi Onyeka | Muorah Chinecherem Onyekachi | Umeasiegbu Adaobi Chidinma "Impact of Social Isolation on Serum Sodium and Cortisol Level in male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46294.pdf Paper URL: https://www.ijtsrd.com/medicine/physiology/46294/impact-of-social-isolation-on-serum-sodium-and-cortisol-level-in-male-wistar-rats/uzoma-reichmann-iheanyi