Comparison of spot urine protein-creatinine ratio with 24-hour urine protein excretion in women with preeclampsia

Objective: To prospectively compare the results of spot urine protein-creatinine (P/C) ratio with 24-hour urine protein excretion in women with preeclampsia. Materials and Methods: A total of 76 pregnant women with preeclampsia were prospectively studied for proteinuria at CAIMS, Karimnagar for a period of one year from August 2013 to July 2014. Urine P/C ratio was determined in a spot midstream sample, and the amount of protein excretion was measured in 24-hour urine collected on the subsequent day. The correlation between the spot P/C ratio and 24-hour urine protein excretion was assessed. Results: There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (r = 0.84; P < .001). The optimal spot P/C ratio cut-off point was 0.20 for 300 mg/24 h of protein excretion (preeclampsia), with a sensitivity, specificity, positive predictive value, and negative predictive value of 91.2%, 87.8%, 94.4%, and 96.8%, respectively.A spot P/C ratio less than 0.19 could exclude preeclampsia with a sensitivity of 100%. Conclusions: We found that there is a significant correlation between the spot urine P/C ratio and 24-hour urine protein excretion in women with preeclampsia. Urine P/C ratio could be used for exclusion of preeclampsia.