Effect of Intrasocket Application of Ozonized Olive Oil Gel on Postsurgical Pain and Soft Tissue Healing of Impacted Mandibular Third Molars Surgery: Split-Mouth Randomized Controlled Trial

Objectives: The aim of this study has been to estimate the analgesic and soft tissue healing effect of applying ozonized oliveoil gel on the extracted site of impacted mandibular third molars postoperatively. Material and Methods: 30 visiting patients with asymptomatic bilateral impacted mandibular third molars were enrolled in this split-mouth single-blinded randomized controlled trial. They form the current sample: (n=60). Randomization was attained using the envelop method, so that each patient was assigned into the corresponding group without the previous knowledge of the researchers. Henceforth, one impacted third molar on one side was extracted and ozonized gel was applied right before suturing; this is for the study side. The control-side impacted molar was extracted 3 weeks later with a ±5-day difference; no substance was applied here, only prescribed antibiotic(1 g Augmentin, twice a day for 7 days). The mean age of the 30 patients was 20.7 ±2.3 (ranging17-25 years). The degree of postsurgical pain was evaluated utilizing the visual analogue scale (VAS) of faces for 7 days post extraction; the number of analgesic (acetaminophen 500 mg)tablets taken was also decided for 7 days later on. Soft tissue healing was evaluated via Landry et al and Gonshor Index on the 7th day postoperatively. Results: The study group demonstrated statistically significant reduction in the degree of pain. The intake of analgesic tablets was, on the other hand, less compared to the control group. When assessed on the 7th day after the surgery, soft tissue healing in the study group proved better than that in control group (p˂0.05). No side effects of the ozonized olive-oil gelwere traced in any patient. Conclusion: This studyshowed significant effect of intrasocket topical application of ozonized gel on pain and soft tissue healing as well as being a sufficient substitute to regular post-surgical antibiotics.