Comparision of Salivary CXCL10 Levels In Smokers and Non-Smokers With Stage III / IV Generalized Periodontal Disease

Aim: The aim of this study was to compare salivary CXCL10 levels with stage III and IV generalized periodontitis in smokers and non-smokers. Patients and Methods: Subjects were classified as stage III and/or IV generalized periodontitis subjects, if they had pocket probing depth (PD) of ≥6 mm and/or clinical attachment level (CAL) of ≥5 mm in >30% of the teeth, tooth loss of ≤4 teeth, radiological bone loss extending to the middle third of root and beyond and vertical bone loss of ≥3mm. 84 subjects were recruited in this study, Group I consists of 42 non-smoker subjects with stage III and/ or stage IV generalized periodontitis and Group II consists of 42 smoker subjects with stage III and/ or stage IV generalized periodontitis. ELISA analysis was performed to determine the salivary CXCL10 levels. Statistics analysis: A student t-test was used to compare continuous variables between two groups and Pearson's correlation test was used to correlate CXCL10 with clinical parameters for both the groups. A p-value of < 0.05 was considered statistically significant. Results: Clinical parameters in both the groups were positively correlated with CXCL10 levels and higher concentrations of CXCL10 were found in group II subjects as compared with the group I subjects (255 ± 193.7 and 84 ± 35.8, P≤0.005). Conclusion: Smoking influences salivary CXCL10 levels in stage III and/or IV generalized periodontitis subjects