Influence of Anti-Mullerian Hormone on ART Outcomes in Infertility Patients of Different Ages

Aging-related intervention by anti-mullerian hormone (AMH) on ART profile were retrospectively examined, and ART outcome of different AMH categories (<1.0, 1.0-3.5, >3.5) was compared. Overall, increased AMH accompanying with endogenous FSH decrement improved oocyte retrieval and maturation. Of those 112 cycles recruited, 77% had ≥1 ng/ml AMH, which accompanied with a significant (p<0.05) reduction in endogenous FSH and age. Improved oocyte retrieval and maturation resulted in better pregnancies than did cycles with <1 ng/ml AMH. A significant decrease in AMH was detected in patients ≥35 years old and great increase in the number of ET embryos in patients maintaining high AMH levels resulted marked increase of the pregnancy rate (11% vs. 69%). However, most AMH effects were disappeared in the 30-34 years group. These results demonstrated that endogenous AMH influenced ART outcomes, and the effect was prominent in patients aged beyond 35 years old, which can predict ART outcomes in middle-aged, infertile patients.