Evaluation Of Bcl-2 Gene Translocation In NSCLC Lung Cancer Based On Age And Sex Segregation

Objectives: Lung cancer is one of the most dangerous cancers in the world. This study was based on the effect of Bcl-2 (B-cell lymphoma 2) gene family on the regulation of cell death (apoptosis) in the body and cancer progression due to high expression of this gene in patients with Non-small cell lung carcinoma (NSCLC), based on age and sex segregation. The presence of this gene near a strong promoter of the immunoglobulin heavy chain (IgH) on chromosome 14 due to translocation increases the overexpression of this gene. Methods: This study was performed on 98 paraffin samples taken from Omid Hospital Research and Medical Center (Mashhad Oncology Institute) by using polymerase chain reaction (PCR). Results: From 98 patients, forty-six patients (46.9%) showed translocation of Bcl-2 gene at three chromosomal breakdown points (it means, the translocation of Bcl-2 gene was positive in 46 patients out of 98 patients), that of which forty-six patients, based on gender segregation, 28 (60.9%) were male and 18 (39.1%) were female. Also, based on age, among these 46 people with Positive Bcl-2 translocation, 10 people (21.7%) were under 55 years old and 36 people (78.3%) were over 55 years old. The three chromosomal breakpoints shown in the above patients were associated with a rate of 43% (20 patients) in the mbr region (Major break-point region), 48% (22 patients) in the mcr region (minor cluster region), and 9% (4 patients) in the icr region (intermediate cluster region). The findings of this study suggest treatment by inhibiting this cancer gene. Conclusion: Suppression of Bcl-2 cancer gene in NSCLC could activate the process of apoptosis in these cancer cells, which may help to find treatment of NSCLC.