Recurrent Aphthous Stomatitis: A mini - Narrative Review

Recurrent aphthous stomatitis (RAS) is a medical term with different meaning for practitioners unclear etiopathogenesis and no definite treatment ladder with lots of challenging issues in over-lap with other disease of oral cavity, for patient recurrent painful lesion in mouth which can im-pact functionally, psychosocially and economically .Diversity of causes and hypothesis each year lead to hundreds of researches to finding out new elements involving patients in this tragic disease but yet pin-pointing a precise etiological factor is difficult.RAS In terms of clinical pres-entation has 3 subtypes: minor (>70% of cases), major (10%), and herpetiform (10%).RAS leads to 25 percent of recurrent oral ulcers in adults and 40 percent in children.Lots of differential di-agnosis for recurrent aphthous ulcerations like idiopathic benign causes, inherited fever syn-dromes, connective tissue disease, gluten-sensitive enteropathy (celiac), ulcerative colitis and Crohn disease should be ruled out by comprehensive history taking and physical exam to find out whether it is related to a systemic inflammatory process or truly idiopathic. More investigation should be done to isolate the etiology of RAS for every case regarding the efficiency of con-ventional and unconventional treatment options, and patients tolerance of side effects.In this re-view of literatures, we trying to summarize results of different studies related to latest break-through and ethiological modalities for RAS to facilitate accurate diagnosis, proper classifica-tion, recognition of provocative factors, and the identification of associated diseases.