The Effect of Xylitol on Bone Alkaline Phosphatase Serum Level and Bone Defect Diameter in Rabbits

Objective: our study aimed to investigate the systemic and topical effect of xylitol on the Bone Alkaline Phosphatase and also on the bone mineral density in rabbits at healing site in femur bone postoperatively. Materials and Methods: Twenty four healthy white male New Zealand rabbits will be taken form the same species, same age, weight and circumstance were chosen were used in this study. All animals were submitted to operation in the femur bone region. The groove of 2mm diameter will made on femur bone was drilled by the heavy-duty dental engine. After operation The rabbits were randomly divided into three group (8 rabbits/group) each group were subdivided into 2 experimental periods (14,28 days) four rabbits for each period as following: Control group, n=8 (hole was no filled by anything), locally treated group n=8 (xylitol powder was condensed well in the hole) and systemically treated group n=8 (hole was not filled by anything but the rabbits received orally of 1mg/kg of xylitol. Bone alkaline phosphates and radiological analysis were measured after 14 and 28 days respectively. Results: Statistical analysis showed significant differences between all groups (control and treated).Biochemical analysis for Bone alkaline phosphatase showed a significant increase in BALP in systemically treated group compared with the control.The estimated of bone healing by measuring diameter of bone defect showed highly significant difference in diameter in defect bony at day 14 between control group (36.0±0.05) in comparison with local treated group and systemic treated group (39± 0.78) and (25± 0.90) respectively. Also we found that significantly difference between local treated group (39± 0.78) and systemic treated group (25± 0.90) in diameter but at day 28 there were no significant difference between control group (28.0±0.55) and local treated group in diameter in defect bony at day 28. Whereas there were significantly difference between control group and local treated group in comparison with systemic treated group (24.0 ± 0.23) at p ≤0.05. Conclusion :This study concluded that xylitol was accelerating bone healing when used topically and systemically this indicted by increase the bone alkaline phosphates and bone mineral density in densometric analysis