Synthesis and Biological Activities of Some New Derivatives Based on 5-Styryl-2-amino-1,3,4-thiadiazole
Journal: Chemical Methodologies (Vol.6, No. 2)Publication Date: 2022-02-01
Authors : Shetha Fadhil Narran; Suad Salman Mohammed; Maab Khattab Omer; Iftikhar Ahmed Hussein; Noor Mohammed Jawad; Batool Karim Shweish;
Page : 83-90
Keywords : 1; 3; 4-Thiadiazle; Amic acid; Imide; anti-bacterial; Anti-fungal;
Abstract
In this research, 5-Styryli-2-amino-1, 3, 4-thiadiazole [C1] was prepared from the reaction of acid 3-phenyl propenoic acid with thiosemicarbazide. Amic acids [C2-C5] were synthesized by reactive compound [C1] with different types of hydrides, then [C2, C4] were treated with AC2O in the presence of NaOAC as a catalyst giving Imide compounds [C6, C7]. The structure of the new derivatives was confirmed via FT-IR spectroscopy, some of which were confirmed via 1H-NMR spectroscopy. Three of these new derivatives were evaluated by their Esherichiacoli, Staphylococcus, and Rhizopus emporium.
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Last modified: 2022-01-03 05:53:12