ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Synthesis and Biological Activities of Some New Derivatives Based on 5-Styryl-2-amino-1,3,4-thiadiazole

Journal: Chemical Methodologies (Vol.6, No. 2)

Publication Date:

Authors : ; ; ; ; ; ;

Page : 83-90

Keywords : 1; 3; 4-Thiadiazle; Amic acid; Imide; anti-bacterial; Anti-fungal;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

In this research, 5-Styryli-2-amino-1, 3, 4-thiadiazole [C1] was prepared from the reaction of acid 3-phenyl propenoic acid with thiosemicarbazide. Amic acids [C2-C5] were synthesized by reactive compound [C1] with different types of hydrides, then [C2, C4] were treated with AC2O in the presence of NaOAC as a catalyst giving Imide compounds [C6, C7]. The structure of the new derivatives was confirmed via FT-IR spectroscopy, some of which were confirmed via 1H-NMR spectroscopy. Three of these new derivatives were evaluated by their Esherichiacoli, Staphylococcus, and Rhizopus emporium.

Last modified: 2022-01-03 05:53:12