POSTNATAL DEVELOPMENT OF THE ENERGY APPARATUS OF RAT BRAIN HISTAMINERGIC NEURONS
Journal: Journal of the Grodno State Medical University (Vol.19, No. 6)Publication Date: 2022-01-10
Authors : S. М. Zimatkin; А. V. Zaerko; K. М. Fedina;
Page : 636-645
Keywords : Histaminergic neurons; brain; postnatal development; energy apparatus; mitochondria; oxidative enzymes; ATP synthase; neuroglobin;
Abstract
Background. Studying the development of the energy apparatus of hypothalamus histaminergic neurons in postnatal ontogenesis is of great interest, given the importance and insufficient knowledge of these cells. Aim of the study. To elucidate postnatal development of the energy apparatus of rat brain histaminergic neurons. Material and methods. The study was performed on 5-, 10-, 20-, 45- and 90-day-old outbred white rats (72 rats). An electron microscopic assessment of changes in the mitochondria structure, a histochemical study of key oxidative enzymes activity of these neurons and immunohistochemical assessment of ATP synthase and neuroglobin content in them were carried out. Results. The development of the energy apparatus of histaminergic neurons in postnatal ontogenesis is accompanied by an increase in the mitochondria number and the relative area occupied by them in the cytoplasm, a change in their shape and an increase in the cristae length in them. Changes at the ultramicroscopic level go parallel with the metabolic differentiation of these neurons, which includes a switch from anaerobic to aerobic energy production, as well as an increase in the expression of ATP synthase and neuroglobin, which determine the functional state of the energy apparatus of these cells. Conclusions. In rat postnatal ontogenesis, a natural development of the energy apparatus of brain histaminergic neurons takes place.
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